Research progress on myeloid-derived suppressor cell and transplantation immune tolerance
10.3969/j.issn.1674-7445.2020.04.002
- VernacularTitle:髓源性抑制细胞与移植免疫耐受研究进展
- Author:
Shun YUAN
1
;
Zhiwei WANG
Author Information
1. Department of Cardiovascular Surgery, People's Hospital of Wuhan University, Wuhan 430060, China
- Publication Type:Research Article
- Keywords:
Myeloid-derived suppressor cell;
Immune tolerance;
Organ transplantation;
Rejection;
Transplantation immunity;
Regulatory T cell (Treg);
Inducible nitric oxide synthase;
Programmed cell death protein-1(PD-1)
- From:
Organ Transplantation
2020;11(4):435-
- CountryChina
- Language:Chinese
-
Abstract:
Myeloid-derived suppressor cell (MDSC) is a type of heterogeneous cell derived from bone marrow, which was first found in tumor. MDSC can inhibit the function of T cell with immunosuppressive effect. In recent years, more and more studies have shown that in the field of organ transplantation, MDSC can also regulate the host's immune function, induce specific immune tolerance, and play a protective role in transplant organs, which is expected to become a new target in clinical treatment of transplant rejection. The biological characteristics of MDSC and the mechanism of immune tolerance induced by MDSC were reviewed in this paper.
