Mechanism of action of microRNA-27a in the development and progression of liver diseases
10.3969/j.issn.1001-5256.2020.07.049
- VernacularTitle:microRNA-27a在多种肝脏疾病发生发展中的作用机制
- Author:
Xin LUO
1
;
Mingyi XU
Author Information
1. Department of Gastroenterology, Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shanghai 200080, China
- Publication Type:Research Article
- Keywords:
micrornas;
fatty liver;
hepatitis;
liver cirrhosis;
liver neoplasms;
liver regeneration
- From:
Journal of Clinical Hepatology
2020;36(7):1666-1668
- CountryChina
- Language:Chinese
-
Abstract:
microRNAs (miRNAs) are low-molecular-weight non-coding RNAs that regulate various physiological and pathological functions through the regulation of gene expression at the post-transcriptional level. More and more evidence has shown that microRNA-27a (miRNA-27a) plays a role in the development and pathogenesis of liver diseases. By reviewing and updating related studies, this article introduces the research advances in the role of miRNA-27a in various liver diseases including fatty liver disease, hepatitis, hepatic fibrosis, and liver cancer and analyzes the role of miRNA-27a in liver regeneration and its potential as a biomarker, so as to provide a reference for future studies and more possibilities for new treatment ideas for chronic hepatic diseases.
