PINK1/Parkin-mediated mitophagy and its mechanism of action in the development and progression of liver diseases
10.3969/j.issn.1001-5256.2020.07.048
- VernacularTitle:PINK1/Parkin介导的线粒体自噬及其在肝脏疾病发生发展中的作用机制
- Author:
Hao ZHANG
1
;
Yue ZHANG
;
Wenwu ZHAO
;
Jingge ZHANG
Author Information
1. The Second Hospital of Hebei Medical University, Hebei Medical University, Shijiazhuang 050017, China
- Publication Type:Research Article
- Keywords:
autophagy;
PINK1/Parkin pathway;
non-alcoholic fatty liver disease;
liver cirrhosis;
carcinoma, hepatocellular
- From:
Journal of Clinical Hepatology
2020;36(7):1663-1665
- CountryChina
- Language:Chinese
-
Abstract:
Mitophagy is the process of selective clearance of damaged mitochondria by autophagy. There are several regulatory mechanisms for mitophagy, and the PINK1/Parkin pathway is considered the main pathway for mitophagy. Recent studies have shown that PINK1/Parkin-mediated mitophagy plays an important role in the pathogenesis of various diseases including Parkinson’s disease. This article introduces the mechanism of PINK1/Parkin-mediated mitophagy and its role in various liver diseases including nonalcoholic fatty liver disease, liver fibrosis, and hepatocellular carcinoma, in order to provide new clues and ideas for the treatment of diseases.
