Mechanism of action of regulatory B cells in the development and progression of autoimmune hepatitis
10.3969/j.issn.1001-5256.2020.07.046
- VernacularTitle:调节性B淋巴细胞在自身免疫性肝炎发生发展中的作用机制
- Author:
Cong TONG
1
;
Xiaoxing XIANG
Author Information
1. Yangzhou University, Yangzhou, Jiangsu 225009, China
- Publication Type:Research Article
- Keywords:
hepatitis, autoimmune； B-lymphocytes； T-lymphocytes
- From:
Journal of Clinical Hepatology
2020;36(7):1655-1657
- CountryChina
- Language:Chinese
-
Abstract:
Autoimmune hepatitis is a type of autoimmune disease and has known pathogenesis at present, which is believed to be associated with immune imbalance in the body. In inflammatory diseases, regulatory B cells (Bregs) inhibits the differentiation of CD4+ T lymphocytes into T helper 1 cells and T helper 17 cells by secreting interleukin-10 (IL-10) to inhibit inflammatory response. Patients with autoimmune hepatitis have reductions in the level of IL-10 in peripheral blood and the number and function of Bregs, which leads to the fact that Bregs cannot effectively inhibit inflammatory response, suggesting that Bregs play a certain role in the pathogenesis of autoimmune hepatitis. This article reviews the mechanism of action of Breg subsets in autoimmune hepatitis.
