Advances in the role of microRNA in the intervention of malignant transformation of precancerous lesions of the liver by regulating the activation of hepatic stellate cells
10.3969/j.issn.1001-5256.2020.07.045
- VernacularTitle:microRNA调控肝星状细胞活化干预肝癌癌前病变的研究进展
- Author:
Jie WU
1
;
Jingtao LI
;
Hailiang WEI
;
Shuguang YAN
;
Yu FAN
;
Yingjun GUO
;
Zhanjie CHANG
Author Information
1. The First Clinical Medical College of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China
- Publication Type:Research Article
- Keywords:
liver neoplasms;
precancerous conditions;
hepatic stellate cells;
microRNAs
- From:
Journal of Clinical Hepatology
2020;36(7):1650-1654
- CountryChina
- Language:Chinese
-
Abstract:
The development and progression of liver cancer have the stages of hepatitis, liver cirrhosis, precancerous lesion, and liver cancer, among which the malignant transformation of precancerous lesions of liver cancer is closely associated with the activation of hepatic stellate cells (HSC). By describing the activation of HSC, the generation of precancerous cells of liver cancer, the formation of inflammatory fibrotic microenvironment, and the association between HSC activation and precancerous lesion, this article points out that microRNAs can affect the malignant transformation of precancerous lesion of liver cancer by regulating the expression of related target genes and HSC activation, and the research in this field is expected to provide new ideas and targets for the prevention and treatment of liver cancer.
