Relationship between dengue viral load and clinical characteristics
10.19485/j.cnki.issn2096-5087.2020.04.003
- VernacularTitle:登革病毒载量与患者临床特征的关系
- Author:
FEI Yunxi
1
;
ZHANG Xiangbo
;
GAO Ling
;
GAO Yidan
;
LI Ge
;
ZHU Xuping
;
SHAO Junbin
;
WANG WANG
;
PAN Jingcao
;
CHEN CHEN
Author Information
1. Zhejiang Chinese Medical University
- Publication Type:Journal Article
- Keywords:
dengue fever viral load clinical characteristics correlation
- From:
Journal of Preventive Medicine
2020;32(4):334-338
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the relationship between dengue virus load and clinical characteristics, so as to provide basis for dengue fever prevention and treatment.
Methods :The dengue viral load and typing of 120 patients in Gongshu District of Hangzhou from June to November 2017 were detected by real-time fluorescent quantitative RT-PCR;the clinical indicators of these dengue patients were collected and their correlation with the viral load was analyzed.
Results:The DNA detection of dengue virus in 120 patients showed that they were all typeⅡ. The median dengue virus load was 3.91×104 copies/mL. All the patients had fever, the average peak temperature was（38.96 ± 0.69）℃. There were 102（85.00%）cases with asthenia;116（96.67%）cases with white blood cell count（WBC）less than 4× 109/L;119（99.17%）cases with platelet count（PLT）less than 100×109/L;114（95.00%）cases with glutamic oxaloacetate transaminase（GOT）more than 40 U/L;81（67.50%）cases with glutamic pyruvate transaminase（GPT）more than 52 U/L;58（48.33%）cases with creatine kinase（CK）more than 210 U/L. There was no significant correlation of dengue virus load with length of hospitalization, peak temperature,duration of fever, WBC,PLT, GOT, GPT and CK（P>0.05）. There were 75（62.50%）severe patients, and their median viral load was 9.29×104copies/mL, which was higher than 5.33×103copies/mL in non-severe patients（P<0.05）.
Conclusion :The dengue virus load is not related with length of hospitalization,peak temperature,WBC,PLT,GOT,GPT and CK,but with the severity of the disease.
