Cervical dystonia in Parkinson’s disease: Retrospective study of later-stage clinical features

Hiroshi Kida; Shiroh Miura; Yoshihiro Yamanishi; Tomoyuki Takahashi; Takashi Kamada; Akiko Yorita; Mitsuyoshi Ayabe; Hideki Kida; Tomoaki Hoshino; Takayuki Taniwaki

Return

Cervical dystonia in Parkinson’s disease: Retrospective study of later-stage clinical features

Author: Hiroshi Kida ^{1
,

2
,

3} ; Shiroh Miura ^{1
,

2
,

3} ; Yoshihiro Yamanishi ^{4
,

5} ; Tomoyuki Takahashi ⁶ ; Takashi Kamada ¹ ; Akiko Yorita ¹ ; Mitsuyoshi Ayabe ^{1
,

2
,

3} ; Hideki Kida ⁷ ; Tomoaki Hoshino ¹ ; Takayuki Taniwaki ^{1
,

2}
Author Information

1. Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University school of Medicine, Kurume
2. 2 Division of Gene Therapy and Regenerative Medicine, Cognitive and Molecular Research Institute of Brain Diseases, Kurume University, Kurume
3. 3 Department of Neurology, Kida Hospital, Shimabara
4. Department of Bioscience and Bioinformatics, Faculty of Computer Science and Systems Engineering, Kyushu Institute of Technology, Iizuka
5. 5 PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama
6. Division of Gene Therapy and Regenerative Medicine, Cognitive and Molecular Research Institute of Brain Diseases, Kurume University, Kurume
7. Department of Neurology, Kida Hospital, Shimabara
Publication Type:Journal Article
Keywords: Parkinson’s disease; cervical dystonia; retrocollis; dopamine agonist; pneumonia
From:Neurology Asia 2018;23(3):245-251
CountryMalaysia
Language:English
Abstract: Objective: Cervical dystonia (CD) is a clinically under-recognized symptom occurring at the later- to end-stages of Parkinson’s disease (PD). The frequency of CD and its influence on prognosis have not been well studied. Here, we conducted an in-depth examination of CD incidence and impact on disease progression in later-stage PD. Methods: We retrospectively reviewed the clinical features of 22 deceased patients with sporadic PD treated at a hospital in Japan from 1983 to 2008. Results: The most common cause of death in PD was pneumonia. CD, in particular retrocollis, was frequent in the later stages of the disease in elderly patients (9/22, 40.9%). Pneumonia incidence increased sharply in the later period with CD. There was a positive trend between CD duration and duration of pergolide use. Conclusion: Analysis revealed that CD increases markedly in late- to end-stage PD, which may be associated with aspiration pneumonia due to dysphagia. Pathological mechanisms underlying CD might be influenced by treatments including dopamine agonists. Prevention of CD may increase quality of life and prolong survival of PD patients.
Full text:7.2018.my007.pdf