Carotid intraplaque hemorrhage in patients with greater than fifty percent carotid stenosis was associated an acute focal cerebral infarction
- Author:
Sangheon Kim
1
;
Hyo Sung Kwak
1
;
Gyung Ho Chung
1
Author Information
1. Radiology and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Republic of Korea
- Publication Type:Journal Article
- Keywords:
Carotid artery;
Magnetic resonance imaging (MRI);
Intraplaque hemorrhage;
Stroke
- From:Neurology Asia
2018;23(3):209-216
- CountryMalaysia
- Language:English
-
Abstract:
The purpose of this study was to assess associations between acute focal cerebral infarction
of anterior circulation and carotid intraplaque hemorrhage (IPH) on magnetization-prepared rapid
acquisition with gradient-echo (MPRAGE) in patients with acute neurologic symptoms. Methods:
From January 2013 to August 2017, 397 patients (median age, 76 years; male, 78.6%) with acute focal
cerebral infarction on diffusion weighted imaging (DWI) were evaluated to determine the maximal
wall thickness of the carotid artery, and to look for IPH on carotid MPRAGE sequences. Carotid
plaques were defined as carotid artery wall thickness greater than 2 mm in at least two consecutive
slices. IPH was defined as the presence in a carotid plaque of MPRAGE signal intensity greater than
200% of the intensity of adjacent muscle. Results: Of these patients with focal cerebral infarction,
165 patients of 195 carotid plaques were included this study. Sixty one (31/3%) carotid plaques of 50
(30.3%) patients were detected MPRAGE positive IPH. Maximal carotid wall thickness and degree
of carotid stenosis were significantly higher in the MPRAGE positive group. MPRAGE positive IPH
in patients with greater than 50% carotid stenosis was associated with an increased risk of an acute
stroke event (p < 0.001), and a 2.64-fold increase in the relative risk of an acute focal stroke, compared
to patients with MPRAGE negative scans.
Conclusions: Carotid MPRAGE positive IPH in patients with greater than 50% carotid stenosis was
associated with acute focal cerebral infarction. MPRAGE positive patients showed higher maximal
carotid wall thickness and a higher percentage of carotid stenosis.
- Full text:7.2018.my002.pdf
