Effectiveness of Prophylactic Use of Antibiotics for Preventing Infection after Acute Stroke ：A Meta-analysis
- VernacularTitle:预防性使用抗菌药物预防急性脑卒中后感染有效性的Meta分析
- Author:
Yijun KE
1
,
2
;
Wei WANG
3
;
Yong JIN
2
;
Jing JU
4
Author Information
1. Dept. of Pharmacy，Anqing Hospital Affiliated to Anhui Medical University，Anhui Anqing 246003，China
2. College of Pharmacy，Anhui Medical University，Hefei 230032，China
3. Dept. of Digestive Medicine，Anqing Hospital Affiliated to Anhui Medical University，Anhui Anqing 246003，China
4. Dept. of Quality Control，Anqing Hospital Affiliated to Anhui Medical University，Anhui Anqing 246003，China
- Publication Type:Journal Article
- Keywords:
Antibiotics;
Prophylactic use;
Effectiveness;
Acute stroke;
Infection;
Pneumonia;
Urinary tract infection
- From:
China Pharmacy
2020;31(13):1640-1645
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To systematically evaluate the effectiveness of prophylactic use of antibiotics for infection after acute stroke，and to provide evidence-based reference for clinical treatment for infection after acute stroke. METHODS ：Retrieved from PubMed，Embase，Cochrane library ，CJFD，VIP，Wanfang database and trial registration platforms such as Central ，randomized controlled trials （RCTs）about the effectiveness of prophylactic use of antibiotics （trial group ）versus placebo or non-prophylactic use of antibiotics （control group ）in the prevention of infection after acute stroke were collected during the inception to Dec. 2019. After data extraction ，the quality of included literatures were evaluated with Cochrane bias risk assessment tool 5.1.0 and modified Jadad scale. Meta-analysis was carried out by using Rev Man 5.3 statistical software. GRADE system was used to analysis the result of Meta-analysis. RESULTS ：A total of 7 RCTs were included ，involving 4 310 patients. The results of Meta-analysis showed that there was no statistical significance in the mortality of patients [RR ＝1.05，95％CI（0.92，1.20），P＝0.47] or the incidence of pneumonia [RR ＝0.92，95％CI（0.77，1.11），P＝0.40] between 2 groups. The total infection rate [RR ＝0.69，95％CI（0.57， 0.85），P＝0.000 3] and the incidence of urinary tract infection [RR ＝0.38，95％CI（0.29，0.49），P＜0.000 01] in the trial group were significantly lower than control group ，and the difference was statistically significant. Result of GRADE showed the out- comes were in high-quality grade. CONCLUSIONS ：Prophylactic use of antibiotics can reduce the total infection rate and the incidence of urinary tract infection after acute stroke ，but can not significantly affect the mortality and the incidence of pneumonia.
