Clinical value of D-dimer and CRP in evaluating the prognosis of 2019 novel coronavirus-infected pneumonia
10.16571/j.cnki.1008-8199.2020.07.014
- VernacularTitle: D-二聚体和C反应蛋白评估新型冠状病毒肺炎预后的临床应用价值
- Author:
Yun-hu PAN
1
,
2
;
Guang CHEN
1
,
2
;
Zhi-hua WANG
2
,
3
;
Guo-ji XIA
2
,
4
;
Mao-zeng LIN
2
,
5
;
Ji-qiu WEN
2
,
6
;
Yuan-cheng HONG
2
,
7
Author Information
1. Department of Respiratory Medicine
2. Wuhan Huoshenshan Hospital, Wuhan 430000, Hubei, China
3. Department of Clinical Laboratory, 907 Hospital of the Joint Logistics Team, Nanping 353000, Fujian, China
4. Department of Respiratory Medicine, 908 Hospital of the Joint Logistics Team, Nanchang 330000, Jiangxi, China
5. Department of Respiratory Medicine, 909 Hospital of the Joint Logistics Team, Zhangzhou 363000, Fujian, China
6. National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, General Hospital of Eastern Theater Command, PLA, Nanjing 210002, Jiangsu, China
7. Department of Respiratory Medicine, 910 Hospital of the Joint Logistics Team, Quanzhou 362000, Fujian, China
- Publication Type:Journal Article
- Keywords:
2019 novel coronavirus-infected pneumonia；D-dimer；CRP；correlation；prognosis
- From:
Journal of Medical Postgraduates
2020;33(7):748-751
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the relationship between the levels of D-dimer and inflammatory factors C-reactive protein（CRP）and prognosis in patients with 2019 novel coronavirus-infected pneumonia（COVID-19）.Methods The clinical data of a total of 242 patients with COVID-19 who were treated in hospital from February 4th 2020 to February 18th 2020 were analyzed retrospectively. According to the classification standard,the patients with COVID-19 were divided into common patients(131 cases), severe patients（88 cases）, and critical patients（23 cases）. The difference between the levels of D-dimer and CRP in patients with pneumonia of different severity and clinical outcomes was compared and the correlation between D-dimer and CRP was analyzed.ResultsThe levels of D-dimer and CRP in severe and critical patients were significantly higher than those in common patients(P<0.05). The levels of CRP in critical patients were significantly higher than those in severe patients(P<0.05). These two indicator levels of patients who died of COVID-19 within 30 dayswere significantly higher than those who survived. Pearson correlation analysis showed that the levels of D-dimer were positively correlated with the levels of CRP(r=0.649，P<0.05).ConclusionD-dimer and CRP are highly expressed in severe and critical patients, and the severe abnormality of the two indicators in the early stage of COVID-19 predicted the poor prognosis. D-dimer and CRP have certain clinical value in evaluating the severity and prognosis of COVID-19.
