Curcumin inhibits Toll-like receptor 4/high mobility group box 1 pathway to protect lipopolysaccharide-induced acute lung injury
- VernacularTitle:姜黄素抑制 TLR4/HMGB1 通路保护脂多糖诱导急性肺损伤的作用
- Author:
Zhen QIN
1
;
Bo WANG
1
;
Zhaoxia TAN
1
;
Shuhua LUO
2
Author Information
1. Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, 610041, P.R.China
2. Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, 610041, P.R.China
- Publication Type:Journal Article
- Keywords:
Acute lung injury;
lipopolysaccharide;
high mobility group box 1;
Toll-like receptor 4;
inflammation factors;
curcumin
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2020;27(06):685-688
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect and mechanism of curcumin on lipopolysaccharide (LPS)-induced acute lung injury. Methods Totally 24 SD rats were randomly divided into a control group, a LPS group and a LPS+curcumin group (n=8 in each group). The degree of lung injury (oxygen partial pressure, wet/dry ratio, pathological scores) and inflammatory levels [tumor necrosis factor (TNF)-α, interleukin (IL)-6, monocyte chemotactic protein (MCP)-1, Toll-like receptor 4 (TLR4), mobility group box 1 protein (HMGB1) expression] of the lung were detected in different groups. Results Oxygen partial pressure was significantly lower in the LPS group than that in the control group (P<0.05), while wet/dry ratio, pathological scores and expression levels of TNF-α, IL-6, MCP-1, TLR4 and HMGB1 were significantly higher in the LPS group than those in the control group (P<0.05). Compared with the LPS group, curcumin significantly reduced wet/dry ratio, pathological scores and expression levels of TNF-α, IL-6, MCP-1, TLR4 and HMGB1 in the LPS+curcumin group (P<0.05), while it significantly improved oxygen partial pressure (P<0.05). Conclusion Curcumin might protect LPS-induced acute lung injury through inhibition of TLR4-HMGB1-inflammation pathway.
