Predictive value of volatile organic compounds in exhaled breath on pulmonary nodule in people aged less than 50 years
- VernacularTitle:呼出气中挥发性有机化合物对<50岁人群肺结节良恶性的预测价值
- Author:
Shaohua XIE
1
,
2
;
Wei DAI
3
;
Mingxin LIU
3
;
Run XIANG
3
;
Tianpeng XIE
3
;
Xiaojun YANG
3
;
Bin HU
3
;
Xiang ZHUANG
3
;
Xiaozun YANG
3
;
Bo TIAN
3
;
Wenwen LI
4
;
Yixiang DUAN
5
;
Qiang LI
3
Author Information
1. 1. Graduate School, Chengdu Medical College, Chengdu, 610500, P.R.China
2. 2. Department of Thoracic Surgery, Sichuan Cancer Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610041, P.R.China
3. Department of Thoracic Surgery, Sichuan Cancer Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610041, P.R.China
4. West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, P.R.China
5. Research Center of Analytical Instrumentation, The College of Life Sciences, Sichuan University, Chengdu, 610064, P.R.China
- Publication Type:Journal Article
- Keywords:
Exhaled breath;
volatile organic compounds;
young and middle-aged;
pulmonary nodule;
prediction model
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2020;27(06):675-680
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of volatile organic compounds (VOCs) on pulmonary nodules in people aged less than 50 years. Methods The 147 patients with pulmonary nodules and aged less than 50 years who were treated in the Department of Thoracic Surgery of Sichuan Cancer Hospital from August 1, 2019 to January 15, 2020 were divided into a lung cancer group and a lung benign disease group. The lung cancer group included 36 males and 68 females, with the age of 27-49 (43.54±5.73) years. The benign lung disease group included 23 males and 20 females, with the age of 22-49 (42.49±6.83) years. Clinical data and exhaled breath samples were collected prospectively from the two groups. Exhaled breath VOCs were analyzed by gas chromatography mass spectrometry. Binary logistic regression analysis was used to select variables and establish a prediction model. The sensitivity, specificity, and area under the receiver operating characteristic (ROC) curve of the prediction model were calculated. Results There were statistically significant differences in sex (P=0.034), smoking history (P=0.047), cyclopentane (P=0.002), 3-methyl pentane (P=0.043) and ethylbenzene (P=0.009) between the two groups. The sensitivity, specificity and area under the ROC curve of the prediction model with gender, cyclopentane, 3-methyl pentane, ethylbenzene and N,N-dimethylformamide as variables were 80.8%, 60.5% and 0.781, respectively. Conclusion The combination of VOCs and clinical characteristics has a certain predictive value for the benign and malignant pulmonary nodules in people aged less than 50 years.
