Analysis of risk factors for lymph node metastasis and prognosis in T1-stage esophageal squamous cell carcinoma
- VernacularTitle:T1 期食管鳞癌淋巴结转移及预后危险因素分析
- Author:
Xiang FEI
1
;
Xinyu WANG
1
;
Qijue LU
1
;
Chunguang LI
1
;
Lixin YANG
1
;
Hezhong CHEN
1
;
Chaojing LU
1
Author Information
1. Department of Thoracic Surgery, Changhai Hospital, Naval Military Medical University, Shanghai, 200433, P.R.China
- Publication Type:Journal Article
- Keywords:
T1-stage esophageal squamous carcinoma;
lymph node metastasis;
prognosis;
risk factor;
surgery
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2020;27(06):657-662
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factors for lymph node metastasis (LNM) and prognosis of T1-stage esophageal squamous carcinoma (ESC). Methods Clinical data of 387 patients with T1-stage ESC who underwent surgical treatment in our hospital from March 2013 to March 2018 were collected. There were 281 males and 106 females aged 60 (41-80) years. The patients were divided into a lymph node metastasis group (n=77) and a non-metastasis group (n=310). The risk factors for LNM and prognosis were analyzed. Results Among 387 patients with T1-stage ESC, 77 (19.9%) patients had LNM. The incidence of LNM was 8.4% (8/95) in T1a-stage patients and 23.6% (69/292) in T1b-stage patients. Univariate analysis showed that tumor size, differentiation degree, depth of invasion and vascular tumor thrombus were associated with LNM (P<0.05). Multivariate logistic regression analysis showed that invasion depth of tumor [OR=2.456, 95%CI (1.104, 5.463), P<0.05] and vascular tumor thrombus [OR=15.766, 95%CI (4.880, 50.938), P<0.05] were independent risk factors for LNM. The follow-up time was 41 (12, 66) months. The 1-year, 3-year and 5-year survival rates were 98.71%, 89.67% and 86.82%, respectively. Univariate analysis showed statistically significant differences in tumor invasion depth, vascular tumor thrombus and LNM between the survival group and the death group. Cox analysis showed that LNM [OR=3.794, 95%CI (2.109, 6.824), P<0.05] was an independent risk factor for prognosis. Conclusion T1-stage ESC patients with deeper invasion or vascular tumor thrombus have a higher risk of LNM. The prognosis of T1-stage ESC with LNM is relatively poor.
