Clinical and prognostic value of cellular immune function in severe patients with coronavirus disease 2019 (COVID-19): A cohort study
- VernacularTitle:新型冠状病毒肺炎重症患者的细胞免疫功能特征及其预后评估价值的队列研究
- Author:
You CHEN
1
,
2
;
Yuchuan LUO
1
,
3
;
Kaijie WANG
4
,
5
;
Hui CAO
6
;
Jianhong LV
1
,
7
;
Jian ZHENG
6
;
Yaqing XU
8
Author Information
1. 1. The 10th Ward of Deparment of Infection, Renmin Hospital of Wuhan University, Wuhan, 430060, P.R.China
2. 2. Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, P.R.China
3. 3. Department of Respiratory, Renmin Hospital of Wuhan University, Wuhan, 430060, P.R.China
4. 4. The 23rd Ward of Department of Infection, Renmin Hospital of Wuhan University, Wuhan, 430060, P.R.China
5. 5. Department of Respiratory, The Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, P.R.China
6. 1. The 10th Ward of Deparment of Infection, Renmin Hospital of Wuhan University, Wuhan, 430060, P.R.China；6. Department of Orthopaedics, Renmin Hospital of Wuhan University, Wuhan, 430060, P.R.China
7. 7. Department of Infection, The Second Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, P.R.China
8. Department of Cadre Health, Renmin Hospital of Wuhan University, Wuhan, 430060, P.R.China
- Publication Type:Journal Article
- Keywords:
Coronavirus disease 2019 (COVID-19);
cellular immunity;
prognosis;
cohort study
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2020;27(06):603-608
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics and prognostic value of cellular immune function in severe patients with coronavirus disease 2019 (COVID-19). Methods A cohort study was conducted to collect the clinical data of 119 severe patients admitted to the Renmin Hospital of Wuhan University (Eastern District) including 60 males (50.4%) and 59 females (49.6%), with an average age of 60.9±14.2 years. The primary endpoint of follow-up was death in the hospital, and the disease outcome classification was the secondary endpoint of follow-up within 30 days after admission. We analyzed the correlation between cellular immune function and COVID-19 prognosis. Results A total of 22 patients died during this process, and 47 patients were severe/critical during the follow-up period. The counts of CD3+, CD4+, CD8+, and CD19+ in the primary endpoint events were significantly different between the survival group and the death group (all P<0.05). The counts of CD3+, CD4+, CD8+, CD19+ in the secondary endpoint events were significantly different between the normal group and the severe/critical group (all P<0.05). The results of the receiver operating characteristic (ROC) curve showed that the area under the cellular immune function curve of dead patients and severe/critical patients had good predictive value (all P<0.05). Conclusion Cell immune function has good clinical and prognostic value for COVID-19.
