Research progress of the role of angiotensin-converting enzyme 2 (ACE2) in the highly pathogenic human coronavirus pneumonia
- VernacularTitle:血管紧张素转换酶 2 在人类高致病性冠状病毒肺炎中作用的研究进展
- Author:
Wenchen WANG
1
,
2
;
Yanming XIA
1
,
2
;
Jianfei ZHU
3
,
4
,
5
;
Songsheng LI
6
;
Jinbo ZHAO
1
,
2
;
Tao JIANG
1
,
2
Author Information
1. Department of Thoracic Surgery, Tangdu Hospital, Air Force Medical University, Xi'
2. an, 710038, P.R.China
3. Department of Thoracic Surgery, Shannxi People&rsquo
4. s Hospital, Xi'
5. an, 710068, P.R.China
6. Department of Surgery, The 944th Hospital, PLA, Jiuquan, 735000, Gansu, P.R.China
- Publication Type:Journal Article
- Keywords:
Highly pathogenic human coronavirus;
angiotensin-converting enzyme 2;
spike protein;
acute respiratory distress syndrome
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2020;27(05):588-596
- CountryChina
- Language:Chinese
-
Abstract:
A novel coronavirus (SARS-CoV-2) that broke out at the end of 2019 is a newly discovered highly pathogenic human coronavirus and has some similarities with severe acute respiratory syndrome coronavirus (SARS-CoV). Angiotensin-converting enzyme 2 (ACE2) is the receptor for infected cells by SARS-CoV. SARS-CoV can invade cells by binding to ACE2 through the spike protein and SARS-CoV-2 may also infect cells through ACE2. Meanwhile, ACE2 also plays an important role in the course of pneumonia. Therefore the possible role of ACE2 in SARS and coronavirus disease 2019 (COVID-19) is worth discussing. This paper briefly summarized the role of ACE2 in SARS, and discussed the possible function of ACE2 in COVID-19 and potential risk of infection with other organs. At last, the function of ACE2 was explored for possible treatment strategies for SARS. It is hoped to provide ideas and theoretical support for clinical treatment of COVID-19.
