Research progress on the role of autophagy in cancer-associated fibroblasts
10.3872/j.issn.1007-385x.2020.06.001
- VernacularTitle:肿瘤相关成纤维细胞中自噬作用的研究进展
- Author:
REN Yinghui
1
;
XU Ke
1
Author Information
1. Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China
- Publication Type:Journal Article
- Keywords:
cancer -associated fibroblasts;
autophagy;
tumor metabolism;
progression;
drug resistance
- From:
Chinese Journal of Cancer Biotherapy
2020;27(6):593-601
- CountryChina
- Language:Chinese
-
Abstract:
Cancer-associated fibroblasts (CAFs) are one of the predominant stromal cells that constitute the tumor microenvironment, and play an essential role in tumor growth, metastasis, chemoresistance and tumor immunity. Autophagy is a cellular process through which cells degrade products in the metabolic process and reuse them to respond to environmental stress. Autophagy is important for tumor initiation, progression and response to therapy, as it connects cellular homeostasis with the extracellular environment that affects immunity and metabolism. This review, by introducing the role of autophagy in CAFs and its regulatory mechanism, summarizes the research progress on studies of autophagy in CAFs and tumor metabolism, progression, metastasis and resistance to therapy.
- Full text:20200601.pdf
