The research progress of Gli1 in the regulation of epithelial mesenchymal transition in oral squamous cell car-cinoma
- Author:
ZHANG Huan-dong
1
,
2
;
XIE Si-ming
1
,
2
Author Information
- Publication Type:Review
- Keywords: Gli1; Epithelial-mesenchymal transition; Hedgehog signaling pathway; Oral squamous cell carcino-ma; Tumor metastasis suppressor
- From: Journal of Prevention and Treatment for Stomatological Diseases 2017;25(5):327-330
- CountryChina
- Language:Chinese
- Abstract: HH (hedgehog) signal pathway consists the hedgehoge ligand (Shh、Ihh and Dhh), the Patch and Smo membrane protein complex and Zinc finger transcription factor Gli (Gli1, Gli2, Gli3). In HH (hedgehog) signaling pathway, Gli1 not only plays a dominant and decisive role in the zinc finger transcription factor Gli (Glioma-associated oncogene homolog) family, but also includes epithelial-mesenchymal transition (EMT) and oral squamous cell carcinoma, tumor invasion and metastasis. The research on oral squamous cell carcinoma and Shh/Gli1 signal axis is rare. In this paper, the squamous cell carcinoma of oral epithelial mesenchymal transformation and correlation study of quality Gli1 is reviewed.
- Full text:Gli1 调控口腔鳞状细胞癌上皮-间充质转化的研究进展.pdf
