Association between -590C/T polymorphisms of interleukin-4 gene and periodontitis: A meta-analysis
10.12016/j.issn.2096-1456.2017.06.003
- Author:
JIA Xaowei
1
;
MA Yan
1
;
ZENG Xiantao
1
;
YUAN Yadi
1
;
LIN Yingmei
1
;
SHAO Jun
1
;
ZHANG Jibin
1
Author Information
1. Department of Stomatology Guangzhou Hospital of Integrated Traditional and West Medicine
- Publication Type:Journal Article
- Keywords:
Periodontitis;
Interleukin-4;
Polymorphism;
Gene;
Meta-analysis
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2017;25(6):354-359
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the relationship between-590C/T polymorphisms of interleukin-4 gene and periodontitis by meta-analysis.
Methods:Databases including PubMed, EMbase, Web of Science, CBM, CNKI, Wanfang and VIP, were searched from their establishment to December 31, 2016. Only case-control studies on the association between -590C/ T polymorphisms of interleukin-4 gene and periodontitis were selected, and the references of those selected studies were searched by hand. Assessment and data extraction were conducted by 2 reviewers independently, and the meta-analysis was performed with the R 3.3.1 software.
Results :The meta-analysis showed that there was no association between the IL-4-590C/T polymorphism and periodontitis susceptibility (T vs C: OR=1.19, 95%CI=0.81~1.76, P =0.37). Subgroup analysis showed that the IL-4 -590 TT was associated with periodontitis in Caucasians (TT vs CT: OR=1.75, 95%CI=1.10 ~ 2.78, P = 0.02), but no significant association in Asians (P =0.63). Meanwhile, IL-4 gene polymorphisms were not significantly associated with the susceptibility of chronic periodontitis (CP) or aggressive periodontitis (AgP) ( e. g. T vs C, CP: P=0.45; AgP: P =0.45).
Conclusion:Based on current evidence, the polymorphisms of IL-4-590C/T are associated with the increased risk of periodontitis in Caucasians.
- Full text:白细胞介素-4-590C-T 基因多态性与牙周炎易感性的Meta 分析.pdf
