Polymorphisms in Apoptosis-Related Genes and TP53 Mutations in Non-Small Cell Lung Cancer.
10.3346/jkms.2011.26.11.1527
- Author:
Eun Young BAE
1
;
Eun Jin LEE
;
Hyo Gyoung KANG
;
Shin Yup LEE
;
Gwang JIN
;
Won Kee LEE
;
Jin Eun CHOI
;
Hyo Sung JEON
;
Jeong Ok LIM
;
Eung Bae LEE
;
Jae Yong PARK
Author Information
1. Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu, Korea. jaeyong@knu.ac.kr
- Publication Type:Brief Communication ; Research Support, Non-U.S. Gov't
- Keywords:
Lung Neoplasms;
Apoptosis;
TP53 Mutation;
Polymorphism, Genetic
- MeSH:
Apoptosis/*genetics;
Carcinoma, Non-Small-Cell Lung/*genetics;
DNA Mutational Analysis;
Female;
*Genes, p53;
Genetic Predisposition to Disease;
Genotype;
Humans;
Lung Neoplasms/genetics;
Male;
Mutation;
*Polymorphism, Single Nucleotide
- From:Journal of Korean Medical Science
2011;26(11):1527-1530
- CountryRepublic of Korea
- Language:English
-
Abstract:
Apoptosis plays an essential role in the elimination of mutated or transformed cells from the body. Therefore, polymorphisms of apoptosis-related genes may lead to an alteration in apoptotic capacity, thereby affecting the occurrence of TP53 mutations in lung cancer. We investigated the relationship between potentially functional polymorphisms of apoptosis-related genes and TP53 mutations in non-small cell lung cancer (NSCLC). Twenty-seven single nucleotide polymorphisms in 20 apoptosis-related genes were genotyped by a sequenome mass spectrometry-based genotyping assay in 173 NSCLCs and the associations with TP53 mutations in the entire coding exons (exons 2-11), including splicing sites of the gene, were analyzed. None of the 27 polymorphisms was significantly associated with the occurrence of TP53 mutations. This suggests that apoptosis-related genes may not play an important role in the occurrence of TP53 mutations in lung cancer.
