Application of nuclear receptor in pathogenesis research and drug development for nonalcoholic fatty liver disease
10.3969/j.issn.1001-5256.2020.06.006
- VernacularTitle:核受体在非酒精性脂肪性肝病发病机制和药物开发中的应用
- Author:
Yiyan CHEN
1
;
Yan LU
Author Information
1. Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200032, China
- Publication Type:Research Article
- Keywords:
non-alcoholic fatty liver disease;
nuclear receptors;
molecular targeted therapy
- From:
Journal of Clinical Hepatology
2020;36(6):1221-1223
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic fatty liver disease (NAFLD) is the most common type of liver disease in developed countries, and in recent years, the prevalence rate of NAFLD tends to increase in China, which brings heavy burden to the social health system. The development and progression of NAFLD are affected by the interaction between multiple influencing factors including genetic and epigenetic factors, transcription factors, hormones, nutrition, and environmental factors. This article reviews the research advances in the role of nuclear receptor in the pathogenesis of NAFLD, in order to deepen the understanding of this disease.
