Research progress on epigallocatechin-3-gallate in the prevention and treatment of oral cancer
10.12016/j.issn.2096-1456.2020.07.012
- Author:
LIU Enyan
1
,
2
;
HE Bing
1
,
2
;
LI Mingyun
1
,
2
Author Information
1. State Key Laboratory of Oral Diseases &
2. National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University
- Publication Type:Review
- Keywords:
natural medicine;
epigallocatechin gallate;
oral cancer;
chemotherapy;
prevention;
oral precancerous state;
oral submucous fibrosis;
signal pathway;
mechanism;
5-fluorouracil;
valdenafilmechanism
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2020;28(7):468-471
- CountryChina
- Language:Chinese
-
Abstract:
Epigallocatechin-3-gallate (EGCG) has antibacterial, anti-inflammatory, antitumor, and other functions. EGCG and its anticancer mechanism are hot research topics in the prevention and treatment of oral cancer. In this paper, the prevention and treatment effects of EGCG on oral cancer and its anticancer mechanism are reviewed. The results show that EGCG can regulate multiple cell metabolic signaling pathways, such as the G protein coupled receptor signaling pathway, mitogen-activated protein kinase (MAPK), and the Wnt signaling pathway, and it can regulate DNA methylation and act on RNA of oral cancer cells directly or indirectly through the oral cancer cell signal transduction network to inhibit the development of oral precancerous lesions and oral cancer. EGCG combined with 5-fluorouracil can enhance the curative effect and reduce adverse effects and is expected to be a new drug for the prevention and treatment of oral cancer.
- Full text:表没食子儿茶素-3-没食子酸酯预防和治疗口腔癌的研究进展2.pdf
