Imaging Studies in Mouse Brain Using Clinical 3T MRI Scanner.
- Author:
Soo Mee LIM
1
;
Eun Mi PARK
Author Information
1. Department of Radiology, Ewha University Mokdong Hospital, School of Medicine, Ewha Womans University, Seoul, Korea. soomee@ewha.ac.kr
- Publication Type:Original Article
- Keywords:
Magnetic resonance imaging (MRI);
Small animal;
Brain;
Imaging diagnosis
- MeSH:
Animals;
Brain;
Cerebral Infarction;
Cerebral Ventricles;
Diffusion;
Gadolinium;
Infarction;
Mice;
Middle Cerebral Artery
- From:Korean Journal of Medical Physics
2010;21(4):348-353
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The purpose of this study was to explore the potentials of a clinical 3T MRI in mouse brains and technical adaptation and optimization. T1-weighted images (T1WI), T2-weighted images (T2WI), FLAIR (Fluid Attenuated Inversion Recovery) images, Gadolinium enhanced T1-weighted images (Gd-T1WI), Diffusion weighted images (DWI) were acquired in brain of 2 mice (weight 20~25 g) with cerebral infarction by occlusion of right middle cerebral artery, 1 hour, 24 hours, 72 hours after infarction and 1 normal mouse brain using clinical 3T MRI scanner. We analyzed differentiation of striatum, ventricle, cerebral cortex, and possibility of detection of acute cerebral infarction. We could differentiate the striatum, ventricle, cerebral cortex on T2WI and on DWI, FLAIR, T1WI, the differentiation of each anatomy of brain was not definite, but acute cerebral infarction was detected on DWI of 1 hour, 24 hours, 72 hours after infarction and on T2WI, FLAIR of 24 hours, 72 hours after infarction. Clinical 3T MRI can be used in differentiation of anatomy of mouse brains and DWI can be helpul in detection of acute cerebral infarction in acute phase. With technical adaptation and optimization clinical 3T MRI can be useful tool for provide preclinical and clinical small animal studies.
