Development of the Early Nutritional Intervention for Elderly Patients with Advanced Cancer: Details of Nutritional Intervention in the Multimodal NEXTAC-ONE Program

Toshimi Inano; Teiko Yamaguchi; Haruka Chitose; Ayuko Umezawa; Hiromu Nagahashi; Masami Okagaki; Takashi Aoyama; Naoharu Mori; Takashi Higashiguchi; Katsuhiro Omae; Keita Mori; Tateaki Naito; Koichi Takayama

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Development of the Early Nutritional Intervention for Elderly Patients with Advanced Cancer: Details of Nutritional Intervention in the Multimodal NEXTAC-ONE Program

VernacularTitle:がん悪液質の高リスクを有する高齢進行がん患者に対する早期栄養介入プログラムの開発─NEXTAC-ONE試験における栄養介入の詳細と評価─
Author: Toshimi INANO ¹ ; Teiko YAMAGUCHI ² ; Haruka CHITOSE ³ ; Ayuko UMEZAWA ³ ; Hiromu NAGAHASHI ⁴ ; Masami OKAGAKI ⁵ ; Takashi AOYAMA ¹ ; Naoharu MORI ⁶ ; Takashi HIGASHIGUCHI ⁷ ; Katsuhiro OMAE ⁸ ; Keita MORI ⁹ ; Tateaki NAITO ¹⁰ ; Koichi TAKAYAMA ¹¹
Author Information

1. Department of Nutrition, Shizuoka Cancer Center
2. Depertment of Health Scicences, Graduate school of Medical Sciences, Kyushu University
3. Nutrition Manegement Office, National Cancer Center Hospital East
4. Department of Nutrition, Niigata Cancer Center Hospital
5. Department of Nutritional Management, University Hospital Kyoto Prefectural University of Medicinee
6. Department of Palliative Care Center, Aichi Medical University Hospital
7. Department of Palliative Care Center, Fujita health University Hospital
8. Department of Clinical Biostatistics, Kyoto University
9. Clinical Research Center, Shizuoka Cancer Center
10. Division of Thoracic Oncology, Shizuoka Cancer Center
11. Department of Pulmonary Medicine, Kyoto Prefectural University of Medicine
Keywords: cancer cachexia; elderly; advanced cancer; multimodal interventions; nutrition counseling
From:Palliative Care Research 2020;15(2):71-80
CountryJapan
Language:Japanese
Abstract: Objective: The aim of this study is to elaborate on the nutritional intervention in a multimodal intervention (the NEXTAC-ONE program) for the elderly with advanced cancer and to evaluate its tolerability Methods: We prospectively recruited patients aged ≥70 years scheduled to receive first-line chemotherapy for advanced pancreatic or non-small-cell lung cancer. Three nutritional intervention were planned in 8-week study period. The nutritional counseling consists of standard nutritional advice, evaluation and support for nutrition impact symptom, and evaluation and support for eating-related distress and food environment problems. We also provide the oral nutritional supplements rich in Branched Chain Amino Acids (BCAA). Results: 29 patients (96%) of a total of 30 study registrants participated in all three nutrition interventions. Median proportion of days in which patients recorded a nutritional diary was 90%. Median consumption of supplements was 99 %. There was no adverse event associated with nutritional intervention. Conclusions: Our nutritional intervention program showed an excellent compliance in the elderly with advanced cancer patients, and our data indicated a potential protective effect on nutritional deterioration.