Role of the Hippo signaling pathway in the development and progression of primary liver cancer
10.3969/j.issn.1001-5256.2020.05.050
- VernacularTitle:Hippo通路在原发性肝癌发生发展中的作用
- Author:
Yinghui HONG
1
;
Chun WANG
;
Mingliang YE
Author Information
1. Hubei Key Laboratory of Intestinal and Colorectal Diseases, Hubei Clinical Center of Intestinal and Colorectal Diseases, Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
- Publication Type:Research Article
- Keywords:
liver neoplasms;
signal transduction;
Hippo pathway
- From:
Journal of Clinical Hepatology
2020;36(5):1171-1174
- CountryChina
- Language:Chinese
-
Abstract:
The incidence rate of primary liver cancer continues to increase around the world, with a younger age of onset and poorer prognosis. As the most classic regulator of cell polarity and density, mechanical signal transduction, cell proliferation, and organ development, the Hippo pathway can promote the development and progression of various cancers including primary liver cancer. YAP, a classic nuclear effector of the Hippo pathway, is significantly upregulated in primary liver cancer and promotes the development of drug resistance. This article aims to investigate the association of the dysregulation of the Hippo signaling pathway with the development and progression of primary liver cancer and analyzes the mechanism of action of the Hippo signaling pathway in the drug resistance of primary liver cancer as an early event of the development of primary liver cancer, which is of great significance for exploring new treatment strategies for primary liver cancer.
