Role of nuclear receptor in the development and progression of primary biliary cholangitis
10.3969/j.issn.1001-5256.2020.05.049
- VernacularTitle:核受体在原发性胆汁性胆管炎发生发展中的作用
- Author:
Haiyan YU
1
;
Yingmei TANG
Author Information
1. Department of Gastroenterology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China
- Publication Type:Research Article
- Keywords:
liver cirrhosis, biliary;
receptors, cytoplasmic and nuclear;
regulatory elements, transcriptional
- From:
Journal of Clinical Hepatology
2020;36(5):1167-1170
- CountryChina
- Language:Chinese
-
Abstract:
Primary biliary cholangitis (PBC) is an chronic progressive intrahepatic cholestasis autoimmune liver disease with unknown causes, and at present, the etiology and pathogenesis of PBC remain unclear. Nuclear receptor is a ligand-dependent transcription factor superfamily that regulates cell growth and differentiation by establishing a relationship between signal molecules and transcriptional responses. The human nuclear receptor family consists of 48 members, including peroxisome proliferator-activated receptors, pregnane X receptor, constitutive androstane receptor, liver X receptors, farnesoid X receptor, vitamin D receptor, and glucocorticoid receptor, which have attracted wide attention. These nuclear receptors regulate the key enzymes and transporter genes of bile acid metabolism at the transcriptional level and thus regulate the level of bile acid in the body and participate in inflammatory response. Bile acid metabolism disorder and persistent inflammation may be the key factors for the development and progression of PBC. This article reviews the research advances in nuclear receptors in the development and progression of PBC, in order to provide a theoretical basis for exploring the pathogenesis of PBC and new therapeutic targets.
