Association between cytochrome P450 gene polymorphism and drug-induced liver injury
10.3969/j.issn.1001-5256.2020.05.045
- VernacularTitle:细胞色素P450基因多态性与药物性肝损伤的关系
- Author:
Qiaoling WANG
1
;
Zhengsheng ZOU
Author Information
1. Peking University Health Science Center, Beijing 100071, China
- Publication Type:Research Article
- Keywords:
cytochrome P-450 enzyme system;
polymorphism, genetic;
chemical and drug induced liver injury
- From:
Journal of Clinical Hepatology
2020;36(5):1150-1153
- CountryChina
- Language:Chinese
-
Abstract:
As the prevalence rate of drug-induced liver injury increases year by year, the pathogenesis of drug-induced liver injury has become the focus of attention. As a large family, CYP450 enzymes participate in almost all oxidative metabolic reactions of drugs in the human liver. Recent studies have shown that CYP450 enzyme gene polymorphisms lead to the differences in pharmacodynamics between individuals, and therefore, exploring the role of CYP450 enzyme gene polymorphisms in drug-induced liver injury may promote the understanding of the pathogenesis of drug-induced liver injury. This article reviews the CYP450 enzyme polymorphisms that have been found to be associated with drug-induced liver injury.
