Cell signaling pathways associated with liver fibrosis and potential therapeutic strategies
10.3969/j.issn.1001-5256.2020.05.043
- VernacularTitle:肝纤维化相关细胞信号转导通路及潜在治疗策略
- Author:
Yangyang DENG
1
;
Shanfei GE
;
Yanqing YU
Author Information
1. Department of Infectious Diseases, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China
- Publication Type:Research Article
- Keywords:
liver cirrhosis;
signal transduction;
therapeutics
- From:
Journal of Clinical Hepatology
2020;36(5):1141-1145
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis is a chronic liver injury caused by various etiologies and a complex pathological change with the activation of hepatic stellate cells as the central link, and various signaling pathways are involved in the regulation of such complex lesions. It has the dual nature of repair and damage and may eventually progress to liver cirrhosis, liver failure, and even liver cancer. In recent years, rapid progress has been made in the basic research on the cell signal transduction pathways associated with liver fibrosis, and some achievements have been made in the research on the treatment strategy of liver fibrosis. This article briefly reviews the cell signaling pathways associated with the development of liver fibrosis, including the JAK/STAT signaling pathway, the NF-κB signaling pathway, the MAPK signaling pathway, the TGF-signaling 1/Smad signaling pathway, the Wnt signaling pathway, the Hedgehog signaling pathway, and the Notch signaling pathway, and also introduces the potential therapeutic strategies for liver fibrosis at present.
