Role of pyroptosis in the pathogenesis of hepatic fibrosis
10.3969/j.issn.1001-5256.2020.05.042
- VernacularTitle:细胞焦亡在肝纤维化发生发展中的作用
- Author:
Chang FAN
1
;
Furong WU
;
Jiafu ZHANG
Author Information
1. Clinical Research Center, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China
- Publication Type:Research Article
- Keywords:
liver cirrhosis;
pyroptosis;
pathologic processes
- From:
Journal of Clinical Hepatology
2020;36(5):1138-1140
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic fibrosis is a reversible pathological reaction of the liver during the self-repair of various chronic liver injuries and can progress to liver cirrhosis and liver cancer. Pyroptosis is a new type of programmed cell death different from apoptosis and necrosis and is closely associated with the pathogenesis of hepatic fibrosis. This article reviews the latest research advances in the definition of pyroptosis, related activation pathways, and its role in hepatic stellate cells, hepatic parenchymal cells, Kupffer cells, and eosinophils, and it is pointed out that pyroptosis can induce liver inflammation, excessively activate hepatic stellate cells, and promote the development and progression of hepatic fibrosis, in order to provide new ideas and potential targets for clinical diagnosis and treatment.
