Apolipoprotien E: A Possible Predictor Risk Factor For Cardiovascular Disease
- Author:
Mastura Sopian1, Sharifah Azdiana Tuan Din2
1
Author Information
1. 1 Oncological and Radiological Science Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200, Kepala Batas, Pulau Pinang, Malaysia 2 Regenerative Medicine Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200, Kepala Batas, Pulau Pinang, Malaysia
- Publication Type:Journal Article
- Keywords:
Apolipoprotein E;
Cardiovascular disease;
LDL
- From:Malaysian Journal of Medicine and Health Sciences
2019;15(SUPPLEMENT 9):173-175
- CountryMalaysia
- Language:English
-
Abstract:
Apolipoprotien E (apoE) polymorphism is a human genetic risk factor and has been well-established to be associated with Alzheimer’s disease, lipid abnormalities, and cardiovascular disease (CVD). ApoE gene polymorphism is reported to correlate with lipid metabolism disturbances and coronary artery stenosis. Furthermore, ε4 allele carriers were found to have poor prognosis in survival rates of post-myocardial infarction. The purpose of the review is to distinguish the possible of apoE gene polymorphism as a determinant for CVD and its association. Preliminary data suggest ε4 allele carrier identification could be beneficial for risk stratification of CVD and initiation of statin therapy as primary intervention. Numerous studies have been done, however, results varied between studies as well as in different population. The evidence presented herein can help describe the risk prediction based on apoE gene polymorphism.
- Full text:11.2019my0555.pdf
