Effects of FRZB mRNA in adjusting WNT signal pathway for prognosis of non-small cell lung cancer
10.13602/j.cnki.jcls.2019.12.17
- VernacularTitle:卷曲相关蛋白mRNA调节WNT信号通路对非小细胞肺癌的预后影响
- Author:
Yaoyu YING
1
;
Bin XU
2
;
Chaofu KE
1
;
Binfeng LU
2
;
Jingting JIANG
2
;
Yueping SHEN
1
Author Information
1. School of Public Health, Soochow University
2. Tumor Biological Treatment Center, the Third Affiliated Hospital of Soochow University, Engineering Technology Research Center for Tumor Immunotherapy of Jiangsu Province, Institute of Cell Therapy of Soochow University
- Publication Type:Journal Article
- Keywords:
frizzled related protein;
lung adenocarcinoma;
lung squamous cell carcinoma;
prognosis;
WNT signal pathway
- From:
Chinese Journal of Clinical Laboratory Science
2019;37(12):946-950
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aimed to reveal the potential clinical and biological functions of frizzled related protein (FRZB) mRNA expression in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC).
Methods:We used the keyword “lung cancer” to search the data through Gene Expression Omnibus (GEO) database attached to NCBI(National Center of Biotechnology) and download the data of LUAD and LUSC from TCGA (The Cancer Genome Atlas) Database. A total of eight LUAD and six LUSC datasets were incorporated in this analysis. We defined cutoff value of FRZB using Cutoff Finder into the two groups to calculate hazard ratio (HR).
Results:We found that high expression level of FRZB mRNA in tumor tissues was a positive prognostic factor for overall survival in LUAD [pooled HR（95%CI）=0.54（0.46-0.64）,P＜0.05 in univariate analysis; pooled HR（95%CI）=0.66（0.54-0.79）,P＜0.05 in multivariate analysis]. Interestingly, there was no similar results in LUSC [pooled HR（95%CI）=1.11（0.67-1.84）,P＞0.05 in univariate analysis; pooled HR（95%CI）=1.13（0.71-1.78）,P＞0.05 in multivariate analysis]. We also found that FRZB may inhibit WNT signal pathway by t-SNE and correlation analysis. By enrichment analysis, FRZB and its most correlated genes were involved in multiple immune-related pathways, such as complement and coagulation cascades, humoral immune response, etc.
Conclusion:High expression of FRZB mRNA in LUAD was associated with better prognosis of lung adenocarcinoma. These results suggest that FRZB may be used as a potential marker for favorable prognosis of lung adenocarcinoma.
