A study on genetic polymorphisms of rs600231 and rs4102217 loci in promoter of MALAT1 gene in Guangxi population
10.13602/j.cnki.jcls.2019.12.16
- VernacularTitle:广西人群MALAT1基因启动子区rs600231和 rs4102217位点遗传多态性
- Author:
Yan WANG
1
;
Chunhong LIU
1
;
Tan TAN
1
;
Ming LEI
1
;
Yanyun HUANG
1
;
Yan LAN
2
;
Yesheng WEI
3
Author Information
1. Department of Laboratory Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities
2. Department of Dermatology, Affiliated Hospital of Youjiang Medical University for Nationalities
3. Department of Laboratory Medicine, Affiliated Hospital of Guilin Medical University
- Publication Type:Journal Article
- Keywords:
metastasis associated in lung adenocarcinoma transcript 1 (MALAT1);
polymorphism;
promoter region;
Guangxi population
- From:
Chinese Journal of Clinical Laboratory Science
2019;37(12):941-945
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the single nucleotide polymorphisms (SNPs) of rs600231A/G and rs4102217 G/C in the promoter region of MALAT1 (metastasis associated in lung adenocarcinoma transcript 1) gene in the healthy population of Guangxi district and analyze the differences in the population among different regions.
Methods:The genotypes of rs600231A/G and rs4102217G/C of 207 healthy individuals in Guangxi were detected by SNPscan high-throughput technique. The genotype and allele frequency distributions were analyzed statistically with the data of HapMap-CEU (European population), HapMap-HCB (Beijing Han population), HapMap-JPT (Japanese population) and HapMap-YRI (African population) published by Human genome Haplotype Map (HapMap).
Results:There were three genotypes of AA (38.2%), AG (46.4%) and GG (15.4%) in rs600231A/G, and the differences were significantly different compared with the polymorphism of Japan and Africa population (HapMap-JPT and HapMap-YRI) (P＜0.05). Compared with HapMap-CEU, the genotype difference was not statistically significant (P＞0.05), but the allele distribution was statistically different (P＜0.05). The rs4102217 G/C polymorphism contained GG(75.4%), CG(23.2%) and CC(1.4%), and the polymorphisms were significantly different from those in European and Japanese populations (P＜0.05). There was no significant difference between gender in the polymorphisms of the two loci (P＞0.05).
Conclusion:The polymorphisms of rs600231A/G and rs4102217G/C in the MALAT1 promoter region were found in Guangxi healthy population, and the distribution of polymorphisms may be different in the population of various regions.
