Research progress of HOXB7 gene in hepatocellular carcinoma

VernacularTitle: HOXB7基因在肝细胞癌中的研究进展
Author: Jia-hong YI ¹ ; Shu-min WANG ¹ ; Hai-le QIU ¹ ; Jun-mei JIA ¹
Author Information

1. The First Clinical Medical College of Shanxi Medical University, Taiyuan 030001, Shanxi,China
Publication Type:Journal Article
Keywords: hepatocellular carcinoma；HOXB7；mechanism；prognosis
From: Journal of Medical Postgraduates 2020;33(5):550-554
CountryChina
Language:Chinese
Abstract: Hepatocellular carcinoma (HCC) is the major histological subtype of primary liver cancer, with a high degree of invasiveness and metastatic potential. HOXB7 is a transcriptional regulator in the homeobox genes (HOX) family, which plays a significant role in the process of DNA synthesis and transcription. HOXB7 can promote the proliferation and invasion of liver cancer cells and other biological processes through a variety of mechanisms. HOXB7 expresses highly in HCC tissues and is closely related to disease progression and poor prognosis. HOXB7 is highly expressed in HCC tissues, and its high expression is closely related to disease progression and poor prognosis. This paper reviews the structure and function of HOXB7 gene, its role in the development of HCC and its prognostic value.