Research on expression and effects of host gene 3 of small nucleolar RNA in malignant tumors

VernacularTitle: 恶性肿瘤中小核仁RNA宿主基因3的表达及作用研究
Author: Cang-hai GUAN ¹ ; Yu-qiao ZHAO ¹ ; Wen-guang SHI ¹ ; Xing-ming JIANG ¹
Author Information

1. Department of General Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150086,Heilongjiang,China
Publication Type:Journal Article
Keywords: long non-coding RNA; SNHG3; expression; regulatory effects
From: Journal of Medical Postgraduates 2020;33(6):638-643
CountryChina
Language:Chinese
Abstract: Increasingly, researches have shown that long non-coding RNA (lncRNA) plays an important role in the oncogenesis and development of various tumors. Small nucleoli RNA host gene 3 (SNHG3) is a newly discovered lncRNA whose abnormally high expression is closely related to the overall survival and prognosis of tumor patients. SNHG3 can regulate the oncogenesis and development of tumors by endogenous competitive adsorption of miRNA, regulating cell cycle, mediating epithelial and mesenchymal transformation, and activating multiple signaling pathways. Therefore, in-depth research on the carcinogenesis mechanism of SNHG3 is helpful for early diagnosis, targeted therapy and prognostic assessment of relevant tumors. This paper reviews latest research progress on the expression and mechanism of SNHG3 in breast cancer, ovarian cancer, kidney cancer, liver cancer, stomach cancer, colon cancer, osteosarcoma and head and neck tumors to provide references for future studies.