Effects of probiotic supplements on insulin resistance in patients with diet-controlled gestational diabetes mellitus
10.16571/j.cnki.1008-8199.2020.06.010
- VernacularTitle: 益生菌补充剂对饮食控制型妊娠期糖尿病患者胰岛素抵抗的影响
- Author:
Xin-yan ZHANG
1
;
Chao FU
1
;
Qi AN
1
;
Jun BAI
;
Li-zhou JIA
Author Information
1. Department of Obstetrics, 2
- Publication Type:Journal Article
- Keywords:
gestational diabetes mellitus;
diet-controlled;
Insulin resistance;
probiotics
- From:
Journal of Medical Postgraduates
2020;33(6):609-612
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveAt present, there are few reports on the therapeutic effect of probiotic supplements in patients with dietary-controlled gestational diabetes mellitus (GDM). This study aims to evaluate the effect of probiotic supplements on insulin resistance in patients with dietary-controlled GDM.Methods122 pregnant women with dietary-controlled GDM who could control blood glucose less than 92 mg/dL through diet and exercise were selected from the Obstetrics Department in Bayannur Hospital from February to December 2018. The patients were randomly divided into two groups: Probiotics Group (probiotic supplements containing bifidobacterium and lactobacillus) and Placebo Group (placebo capsules). 61 patients in each group were treated continuously for 4 weeks. The main evaluation index was the mean difference of fasting blood glucose, fasting plasma insulin and insulin resistance index (HOMA-IR) between the two groups, and the secondary evaluation index was the change of maternal weight after intervention.ResultsThe increase of fasting blood glucose [(0.59±6.42)mg/dL], fasting plasma insulin [(1.14±1.95)mIU/mL] and HOMA-IR (0.27±0.45) in the Probiotics Group after intervention were significantly lower than those in the Placebo Group [(4.78±7.47 mg/dL), (3.86±1.82) mIU/mL, (0.86±0.59)], and the difference was statistically significant (P < 0.05). There was no significant difference in total weight gain, neonatal birth weight and neonatal hypoglycemia between the two groups (P>0.05).ConclusionDuring pregnancy, probiotic supplements for four weeks in patients with dietary-controlled GDM can reduce fasting blood glucose and increase insulin sensitivity. Therefore, probiotic supplements can be used as adjunctive therapy for blood glucose control in patients with dietary-controlled GDM.
