Role of Clinical Pharmacists in Anti-infective Therapy for Patients with Septic Shock in ICU
- VernacularTitle:临床药师在ICU感染性休克患者抗感染治疗中的作用
- Author:
Yufang LIAO
1
;
Fei LI
1
;
Jianhua YAN
2
;
Ke SI
3
Author Information
1. Dept. of Pharmacy,Chongqing Qianjiang Central Hospital,Chongqing 409099,China
2. Dept. of Clinical Laboratory,Chongqing Qianjiang Central Hospital,Chongqing 409099,China
3. Dept. of Critical Care,Chongqing Qianjiang Central Hospital,Chongqing 409099,China
- Publication Type:Journal Article
- Keywords:
Clinical pharmacist;
ICU;
Septic shock;
Anti-infection;
Pharmaceutical care
- From:
China Pharmacy
2020;31(11):1382-1386
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the role of clinical pharm acists in anti-infective therapy in patients with septic shock in the ICU. METHODS :A total of 180 patients with septic shock were retrospectively collected from ICU of Chongqing Qianjiang Central Hospital during Jan.-Dec. 2018. According to whether clinical pharmacists participated in anti-infective therapy in the whole process,the patients were divided into intervention group (92 cases)and control group (88 cases). Both groups were given routine treatment according to clinical diagnosis ;on this basis ,clinical pharmacists participated in the whole anti-infective therapy of the intervention group ,including participating in pharmaceutical rounds ,formulating anti-infective programs ,guiding nurses to implement anti-infective plan ,and providing pharmaceutical care for patients. The effectiveness ,safety and antibiotics clinical use indexes(such as proportion ,treatment course and cost of key monitored drugs )were evaluated in 2 groups. RESULTS :The cure rate of intervention group (98.91%)was significantly higher than that of control group (93.18%),while the incidence of ADR in the intervention group (8.70%)was significantly lower than control group (23.86%). The use of antibiotics types was more rational(the proportion of carbapenems used in intervention group and control group were 20.65%,36.36%;those of quinolones were 15.22%,28.41%,respectively);the duration of antibiotics use in the intervention group [ (15.18±2.25)d] was significantly shorter than control group [ (19.84±3.81)d]. The cost of antibiotics per capita [ (2 846.99±712.48)yuan] was significantly lower than control group [ (3 991.26±577.82)yuan],with statistical significance of all above (P<0.05 or P<0.01). CONCLUSIONS : Clinical pharmacists participating in the anti-infective treatment of ICU patients with septic shock and providing pharmaceutical care,can improve the anti-infective effect ,reduce adverse drug reactions and drug-induced diseases ,optimize the use of antibiotics and reduce medical cost.