Expression differences of serum tumor markers in different molecular subtypes of breast cancer and their correlations with recurrence and metastasis
10.13602/j.cnki.jcls.2019.12.04
- VernacularTitle:不同分子分型乳腺癌血清肿瘤标志物的表达差异与肿瘤复发转移的影响因素
- Author:
Xiangjun CHENG
1
;
Lu YANG
1
;
Wei ZHANG
1
;
Jiexin ZHANG
1
;
Lujiang YI
1
;
Shiyang PAN
1
Author Information
1. Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University
- Publication Type:Journal Article
- Keywords:
breast cancer;
tumor marker;
molecular subtype;
recurrence and metastasis
- From:
Chinese Journal of Clinical Laboratory Science
2019;37(12):893-896
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression differences of serum tumor markers, such as CEA, CA125 and CA15-3, in different molecular subtypes of breast cancer and their correlations with recurrence and metastasis.
Methods:The medical records and follow-up data from 212 patients with breast cancer were retrospectively analyzed. According to the expression of hormone receptor, breast cancer were divided into four molecular subtypes: Luminal A, Luminal B, Her-2 overexpression and Basal-like. The clinical characteristics and levels of CEA, CA125 and CA15-3 in different molecular subtypes of breast cancer patients before operation were compared, and the factors influencing the recurrence and metastasis of breast cancer were analyzed.
Results:There were differences in the expression levels of tumor markers for different molecular subtypes of breast cancer. The expression levels of CA15-3 in patients with Her-2 overexpression were significantly higher than that with Luminal A, Luminal B or Basal-like (χ 2 =7.98,P=0. 04). The differentiation degree of tumor cells in different molecular subtypes of breast cancer was different, and the proportion of low differentiation in the patients with Her-2 overexpression was significantly higher than that with Luminal A, Luminal B or Basal-like (χ 2 =12.42,P=0.006). There was also differences in the recurrence and metastasis of tumor for 4 subtypes of breast cancer, and the highest recurrence and metastasis rate existed in the patients with Her-2 overexpression (F=8.69,P=0.034). The multivariate Cox regression analysis showed that tumor diameter, degree of tissue differentiation and presence or absence of vascular tumor thrombus were independent risk factors for the recurrence and metastasis of breast cancer patients (all P＜0.05).
Conclusion:The breast cancer patients with Her-2 overexpression have high levels of CA15-3 and poor prognosis, which suggests that the individualized treatment of breast cancer should be combined with molecular subtyping, tumor markers and related risk factors.
