A evaluation of coagulation biomarkers for diagnosis and therapeutic monitoring of deep venous thrombosis of lower extremities
10.13602/j.cnki.jcls.2019.09.07
- VernacularTitle:血栓分子标志物对下肢深静脉血栓形成的诊断及抗凝疗效的评价
- Author:
Meng WEN
1
;
Huiru ZHAO
1
;
Yujing ZHAO
1
;
hui CAO
1
;
Yuying CHEN
2
;
Wenjie ZHANG
2
;
Xiangyu CAO
2
;
Jun WU
1
Author Information
1. Department of Laboratory Medicine, Beijing Jishuitan Hospital
2. The 4th Affiliated Hospital of Peking University
- Publication Type:Journal Article
- Keywords:
deep vein thrombosis;
thrombin-antithrombin complexes;
plasmin-α[DK(]2[DK)]-plasmin inhibitor complexes;
tissue-type plasminogen activator-inhibitor complexes;
thrombomodulin;
efficacy monitor
- From:
Chinese Journal of Clinical Laboratory Science
2019;37(9):671-674
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the changes of molecular markers of thrombosis in patients with deep venous thrombosis of lower extremities and analyze their value in the detection of venous thrombosis and evaluate the therapeutic effects.
Methods:In case-control study, we selected traumatic patients after surgery from Beijing Jishuitan Hospital during December 2018 to May 2019. A total of 64 patients with thrombosis were in DVT group, 39 patients without thrombosis were in non-DVT group, and 28 healthy subjects in the same period were in healthy control group. Venous blood samples were taken from all these people. Coagulation parameters thrombin-antithrombin complexes (TAT), plasmin-α2-plasmin inhibitor complexes (PIC) and tissue-type plasminogen activator-inhibitor complexes (t-PAIC) were detected at first diagnosis and one month after rivaroxaban anticoagulation therapy beginning. The differences of the markers between these groups were compared.
Results:The coagulation markers of the patients with lower extremity deep venous thrombosis increased significantly at diagnosis. The levels of plasma TAT, PIC, t-PAIC and sTM in DVT group were significantly higher than those in non-DVT group (P＜0.05). The levels of plasma TAT, PIC and t-PAIC in DVT group were higher than those in healthy control group (P＜0.05). There was no significant difference in sTM level between DVT group and healthy control group (P＞0.05). The results and changes of TAT, PIC, t-PAIC in the patients before and after one month of anticoagulation therapy were statistically different (P＜0.05) in comparison.
Conclusion:The molecular markers of thrombosis, TAT, PIC and t-PAIC, could effectively detect deep venous thrombosis of lower extremities and showed significant efficacy in evaluating the efficacy of anticoagulation therapy.
