Calibration and performance verification of gas chromatography-mass spectrometer for urine organic acid detection after annual maintenance
10.13602/j.cnki.jcls.2019.03.17
- VernacularTitle:用于尿液有机酸检测的气相色谱-质谱联用仪年度维护保养后的校准及性能验证
- Author:
Xiaoying YU
1
;
Daojie ZHANG
1
Author Information
1. Department of Biochemical Genetics, Beijing Shengyuan Huiren Clinical Laboratory
- Publication Type:Journal Article
- Keywords:
gas chromatography-mass spectrometer;
calibration;
performance verification;
genetic metabolic disease
- From:
Chinese Journal of Clinical Laboratory Science
2019;37(3):233-236
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a method of calibration and performance verification of the GCMS-QP 2010 Ultra gas chromatography-mass spectrometer for urine organic acid detection after annual maintenance, so as to ensure that the performance of the detection system can continuously meet the detection needs.
Methods:According to the requirements of the equipment manufacturer and the Calibration Specifications for Benchtop Gas Chromatography-Mass Spectrometer, the gas chromatography-mass spectrometer was calibrated after annual maintenance. According to the CNAS-CL02-A003 Guidance on the Application of Accreditation Criteria for the Medical Laboratory Quality and Competence in the Field of Clinical Chemistry, the analytical performance of the maintained gas chromatography-mass spectrometer was validated.
Results:The calibration results of quality range, quality accuracy, resolution, signal-to-noise ratio and repeatability were all met the requirements. The detection results of internal quality control materials were under control, and the results of retained samples kept unchanged.
Conclusion:The calibration and performance verification method of the gas chromatography-mass spectrometer for urine organic acid detection after annual maintenance is established successfully, which is of importance for providing accurate and reliable results of urine organic acid.
