Prognostic significance of high hyperdiploid and triploid/tetraploid acute myeloid leukemia
10.13602/j.cnki.jcls.2019.03.05
- VernacularTitle:高超二倍体、三/四倍体染色体核型在急性髓细胞白血病中的预后意义
- Author:
Minjun LOU
1
;
Jiahui HOU
1
;
Lili QIAN
1
;
Xiaochun WANG
1
;
Linchao ZHU
1
;
Ying YU
1
Author Information
1. Department of Clinical Laboratory, The First Affiliated Hospital of Zhejiang Chinese Medical University
- Publication Type:Journal Article
- Keywords:
acute myeloid leukemia;
high hyperdiploid;
triploid/tetraploid;
prognosis
- From:
Chinese Journal of Clinical Laboratory Science
2019;37(3):183-185
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the biological characteristics of high hyperdiploid and triploid/tetraploid acute myeloid leukemia (HH/TT-AML) and its relationship with prognosis.
Methods:The clinical data of 28 patients with newly diagnosed HH/TT-AML during March 2006 and June 2017 were retrospectively analyzed, and the factors influencing prognosis were analyzed by the Kaplan-Meier method.
Results:The karyotypes of HH/TT-AML patients were mainly 49 chromosomes, accounting for 39.3% (11/28), followed by 50-55 chromosomes, accounting for 32.1% (9/28). The karyotypes of high hyperdiploid acute myeloid leukemia (HH-AML) patients were more likely to be +8 (77.3%, 17/22) or +21 (54.5%, 12/22). The survival analysis showed that the overall survival rate of HH/TT-AML patients with -5/5q-, -7/7q-, -17/der(17p) or der(3q) was significantly lower than that without these abnormalities (4.1 months vs 10.1 months,P＜0.05). There was no significant difference in the overall survival rate between triploid/tetraploid acute myeloid leukemia (TT-AML) patients and HH-AML patients (8.4 months vs 7.2 months,P＞0.05). The overall survival rate of the patients with allogeneic hematopoietic stem cell transplantation was significantly longer than that with chemotherapy alone (25.4 months vs 4.1 months,P＜0.01).
Conclusion:HH/TT AML patients are highly heterogeneous. The identification of poor prognosis-related chromosome abnormalities is helpful for the stratification of prognosis. The overall survival time of these patients is short. Early allogeneic hematopoietic stem cell transplantation after remission by combination chemotherapy can significantly improve the prognosis of these patients.
