The role and molecular mechanisms of long noncoding RNAs in cardiac diseases
10.16438/j.0513-4870.2020-0099
- VernacularTitle:长链非编码RNA调节心脏疾病的作用与分子机制
- Author:
Zhen-wei PAN
1
;
Bao-feng YANG
1
Author Information
1. The State-Province Key Laboratories of Biomedicine Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Department of Pharmacology, College of Pharmacy, Harbin Medical University, Research Unit of Noninfectious Chronic Diseases in Frigid Zone, Chinese Academy of Medical Sciences, Harbin 150081, China
- Publication Type:Research Article
- Keywords:
long noncoding RNAs;
heart failure;
cardiac ischemia;
arrhythmia;
myocardial fibrosis;
biomarker
- From:
Acta Pharmaceutica Sinica
2020;55(5):773-780
- CountryChina
- Language:Chinese
-
Abstract:
Long noncoding RNAs (lncRNAs) are a class of RNAs that are more than 200 nucleotides in length with no protein coding property. LncRNAs are involved in almost every cellular process through multiple mechanisms. LncRNAs can directly bind to molecules in cells such as proteins, RNA, and DNA, to regulate cellular functions by influencing processes including transcription, translation, and molecular transporting. Recent researches showed lncRNAs are key regulators of serious cardiac diseases, especially in development and progression of cardiac ischemia, arrhythmia, cardiac fibrosis, and heart failure. This article mainly summarizes the function and mechanism of lncRNAs in cardiac diseases and gives reasonable prospect of lncRNAs in the future.
