Research advances of glutamine metabolism-related targets in tumor treatment
10.16438/j.0513-4870.2019-1048
- VernacularTitle:谷氨酰胺代谢相关靶点在肿瘤治疗中的研究进展
- Author:
Ting ZHANG
1
;
Jing LIU
1
;
Ya DING
1
Author Information
1. Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China
- Publication Type:Research Article
- Keywords:
glutamine;
metabolic reprogramming;
cancer;
target;
therapy
- From:
Acta Pharmaceutica Sinica
2020;55(5):813-820
- CountryChina
- Language:Chinese
-
Abstract:
Metabolic reprogramming is an important feature of tumor cell metabolism. Glutamine, as a conditionally essential amino acid, provides material and energy for cell growth and maintains the redox homeostasis of tumor cells. This article reviews the role of glutamine in tumorigenesis, development and metastasis, discusses the relationship between glutamine and key biomacromolecules, and provides ideas for finding new targets in cancer therapy.
