A new cytochalasan compound from endophyte Chaetomium globosum WQ in Imperata cylindrical
10.16438/j.0513-4870.2019-0966
- VernacularTitle:白茅内生菌Chaetomium globosum WQ产生的一个新细胞松弛素化合物
- Author:
Wen-jing XIA
1
;
Xing-qin CAO
1
;
Qin LIU
2
;
Sha-sha WANG
1
;
Li SHEN
1
Author Information
1. Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225001, China; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou 225001, China
2. Jiangsu Lixiahe Institute of Agricultural Science, Yangzhou 225007, China
- Publication Type:Research Article
- Keywords:
italic>Imperata cylindrical;
endophyte;
italic>Chaetomium globosum;
secondary metabolites;
20-iso-chaetoglobosin E;
cytochalasan compound
- From:
Acta Pharmaceutica Sinica
2020;55(5):967-970
- CountryChina
- Language:Chinese
-
Abstract:
italic>Chaetomium globosum WQ, an endophyte derived from Imperata cylindrical, can produce abundant cytochalasan compounds through solid state fermentation. Based on previous research and guided by 1H NMR spectrum and TLC, a new cytochalasan compound was isolated from the ethyl acetate extract of a solid culture of C. globosum WQ using silica gel column chromatography, gel filtration over Sephadex LH-20 and HPLC. The new compound was characterized as 20-iso-chaetoglobosin E (1) by a combination of spectroscopic (HR-MS, 1D and 2D NMR) analyses.
