A new cytochalasan compound from endophyte Chaetomium globosum WQ in Imperata cylindrical

VernacularTitle:白茅内生菌Chaetomium globosum WQ产生的一个新细胞松弛素化合物
Author: Wen-jing XIA ^{1
,

2} ; Xing-qin CAO ^{1
,

2} ; Qin LIU ³ ; Sha-sha WANG ^{1
,

2} ; Li SHEN ^{1
,

2}
Author Information

1. Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225001, China
2. Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou 225001, China
3. Jiangsu Lixiahe Institute of Agricultural Science, Yangzhou 225007, China
Publication Type:Research Article
Keywords: italic>Imperata cylindrical; endophyte; italic>Chaetomium globosum; secondary metabolites; 20-iso-chaetoglobosin E; cytochalasan compound
From: Acta Pharmaceutica Sinica 2020;55(5):967-970
CountryChina
Language:Chinese
Abstract: italic>Chaetomium globosum WQ, an endophyte derived from Imperata cylindrical, can produce abundant cytochalasan compounds through solid state fermentation. Based on previous research and guided by ¹H NMR spectrum and TLC, a new cytochalasan compound was isolated from the ethyl acetate extract of a solid culture of C. globosum WQ using silica gel column chromatography, gel filtration over Sephadex LH-20 and HPLC. The new compound was characterized as 20-iso-chaetoglobosin E (1) by a combination of spectroscopic (HR-MS, 1D and 2D NMR) analyses.