Current status and future of non-genomic effects of phytoestrogens
10.16438/j.0513-4870.2019-0959
- VernacularTitle:植物雌激素非基因组效应研究的现状与将来
- Author:
Xin-yue YANG
1
,
2
;
Hai-xin LIU
1
,
2
,
3
;
Shuang HE
1
,
2
;
Rui SHAO
1
,
2
;
Yu-xin FENG
1
,
2
;
Yan ZHU
1
,
2
Author Information
1. Tianjin Modern Chinese Medicine Key Laboratory, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
2. Tianjin International Biomedical Research Institute, Chinese Medicine New Drug Research and Development Center, Tianjin 300457, China
3. Shanxi University of Traditional Chinese Medicine, Taiyuan 030619, China
- Publication Type:Research Article
- Keywords:
phytoestrogen;
estradiol;
nongenomic effect;
estrogen receptor alpha
- From:
Acta Pharmaceutica Sinica
2020;55(5):854-860
- CountryChina
- Language:Chinese
-
Abstract:
Phytoestrogens exhibit various pharmacological estrogen-like effects, such as in the prevention and treatment of osteoporosis, cardiovascular diseases, tumors, etc., but the specific mechanism is still unclear. In recent years, estrogen receptor alpha-mediated rapid non-genomic effects have been identified to play an important role in the pathogenesis of estrogen-related diseases. The research of phytoestrogens exerting pharmacological effects through non-genomic effects has also received increasing attention. This article summarizes the research progress in estrogen receptor alpha-mediated non-genomic effects and analyzes the possible involvement of rapid non-genomic effects in certain pharmacological effects of phytoestrogens. The future prospects of estrogen receptor-mediated non-genomic effects by phytoestrogens are also discussed.
