Progress in oligosaccharide extraction, separation and structural analysis by mass spectrometry
10.16438/j.0513-4870.2019-0842
- VernacularTitle:寡糖提取分离与质谱结构解析研究进展
- Author:
Lian-jie CUI
1
,
2
;
Ke LI
1
,
3
;
Zhen-yu LI
1
;
Xue-mei QIN
1
;
Yu-guang DU
4
Author Information
1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
3. Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China
4. Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China
- Publication Type:Research Article
- Keywords:
oligosaccharide;
extraction and separation;
mass spectrometry;
ionization;
structural analysis
- From:
Acta Pharmaceutica Sinica
2020;55(5):843-853
- CountryChina
- Language:Chinese
-
Abstract:
Oligosaccharides play important roles in many biological processes and have great medicinal potential. The structure-activity study of oligosaccharides is complicated by the diversity and complexity of their structures. This review summarizes the state of oligosaccharide structural analysis in recent years. The ionization methods and dissociation rule of acid oligosaccharides, neutral oligosaccharides and glycopeptides in mass spectrometry are discussed and the methods of extraction and purification of oligosaccharides, the suitable mass spectrometry models for different types of oligosaccharides, and the advantages and disadvantages of different mass spectrometry models are introduced. We believe that this review will be helpful for the further investigation of these important biological substances.
