Prophylactic Effect of Brimonidine 0.15% on IOP Elevation After Intravitreal Triamcinolone Acetonide Injection.
10.3341/jkos.2008.49.5.743
- Author:
Myung Won LEE
1
;
Sung Eun KYUNG
;
Moo Hwan CHANG
Author Information
1. Department of Ophthalmology, Dankook University College of Medicine, Cheonan, Korea. changmh@dankook.ac.kr
- Publication Type:Clinical Trial ; Original Article ; Randomized Controlled Trial
- Keywords:
Brimonidine;
Intravitreal injection;
Intraocular pressure;
Triamcinolone acetonide
- MeSH:
Eye;
Humans;
Incidence;
Intraocular Pressure;
Intravitreal Injections;
Optic Nerve;
Prospective Studies;
Quinoxalines;
Retina;
Risk Factors;
Triamcinolone;
Triamcinolone Acetonide;
Brimonidine Tartrate
- From:Journal of the Korean Ophthalmological Society
2008;49(5):743-752
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The purpose of this study was to investigate the prophylactic effect of brimonidine 0.15% on intraocular pressure (IOP) elevation and the risk factors for its elevation after intravitreal triamcinolone acetonide injection (IVTA). METHODS: A prospective, randomized clinical trial was conducted on 67 eyes of 64 patients undergoing IVTA. Eyes were randomly divided into two groups, those which had used brimonidine 0.15% (40 eyes) and those which had not used it (27 eyes). IOP was measured preoperatively, at one week, and monthly until six months post-injection in each group. RESULTS: The mean post.injection IOP at one week was 11.93+/-3.36 mmHg for the group that had used brimonidine and 13.58+/-3.25 mmHg for the group that had not used it. The difference between the two groups was statistically significant at one week (p=0.049), but others were not statistically significant. An elevation in the IOP of more than 22 mmHg was seen in 8 eyes (20%) in the group using brimonidine and in 7 eyes (25.9%) in the group not using brimonidine. There was no difference in the incidence of IOP elevation between the two groups. CONCLUSIONS: Prophylactic use of brimonidine 0.15% will prevent sudden IOP elevation and will, therefore, prevent damage to the retina and optic nerve. However, in the long term, there is no prophylactic effect of brimonidine 0.15% on IOP elevation because there was no difference in the incidence of IOP elevation of more than 22 mmHg between the two groups.
