Research progress on carbapenem-resistant Klebsiella pneumoniae infection in organ transplantation
10.3969/j.issn.1674-7445.2020.03.015
- VernacularTitle:器官移植中耐碳青霉烯类肺炎克雷伯菌感染的研究进展
- Author:
Weiwang LIU
1
;
Xiao WANG
;
Chuanchang LI
Author Information
1. Department of Geriatrics, Xiangya Hospital of Central South University, Changsha 410008, China
- Publication Type:Research Article
- Keywords:
Organ transplantation;
Carbapenem-resistant Klebsiella pneumoniae;
Infection;
Donation after cardiac death;
Delayed graft function;
Intensive care unit;
Ceftazidime-avibactam;
Phage
- From:
Organ Transplantation
2020;11(3):405-
- CountryChina
- Language:Chinese
-
Abstract:
Klebsiella pneumoniae (KP) is a common conditional pathogen, and also one of the common pathogens causing infection in immunocompromised patients, with its infection rate increasing year by year. Carbapenem antibiotics are effective drugs to control KP infection. But with the widespread use of carbapenem antibiotics, carbapenemresistant Klebsiella pneumoniae (CRKP) appears and increases year by year. Organ transplant recipients are at high risk of CRKP infection due to the suppressed immune system. Once drug-resistant bacteria infection occurs, it is often difficult to control and the survival rate of transplant organs is reduced, which brings great challenges to clinical treatment. In this article, the current status and treatment progress of CRKP infection in organ transplantation are summarized.
