The function of regulatory immunological cell in xenotransplantation immunity
10.3969/j.issn.1674-7445.2020.03.001
- VernacularTitle:调节性免疫细胞在异种移植免疫中的作用
- Author:
Bingyi SHI
1
;
Wen CHEN
;
Zhijia LIU
Author Information
1. Organ Transplantation Institute of the 8th Medical Center of Chinese People s Liberation Army General Hospital, Beijing 100091, China
- Publication Type:Research Article
- Keywords:
Regulatory immunological cell;
Xenotransplantation;
Rejection;
Transplantation immunity;
Regulatory T cell (Treg);
Regulatory dendritic cell (DCreg);
Follicular regulatory T cell (Tfr);
Regulatory B cell (Breg)
- From:
Organ Transplantation
2020;11(3):321-
- CountryChina
- Language:Chinese
-
Abstract:
Xenotransplantation is the most promising method to resolve the organ shortage problem in the future. In recent years, the advances in gene editing and immunological technique have driven the rapid development of xenotransplantation. However, there are still many insurmountable obstacles in the clinical application of xenotransplantation, among which the rejection is the most important cause of the xenotransplantation failure. Regulatory immunological cells are a group of immunological cells with the negative regulation function in the body, which can inhibit allotransplantation rejection and prolong the survival time of the graft. This paper summarized the research progress of regulatory immunological cells in the xenotransplantation application in recent years, providing reference for the prevention and treatment of xenotransplantation rejection.
