Preparation and Quality Evaluation of Imperatorin Ultradeformable Liposomes Gel
- VernacularTitle:欧前胡素柔性脂质体凝胶的制备及质量评价
- Author:
Xuehui CUI
1
,
2
;
Shihong CHEN
1
,
2
;
Jindi QIU
1
,
2
;
Junfeng BAN
1
,
2
;
Nannan YANG
1
,
2
;
Qingchun NI
3
;
Zhaoyan PAN
4
;
Qingchun XIE
1
,
2
;
Yanzhong CHEN
1
,
2
;
Zhufen LYU
1
Author Information
1. Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems/ New Drug R&D Center，Guangdong Pharmaceutical University，Guangzhou 510006，China
2. R&D Innovation Team for Controlled-release Microparticle Drug Delivery System/Guangdong Provincial Engineering Center of Topical Precision Drug Delivery System，Guangdong Pharmaceutical University，Guangzhou 510006，China
3. Guangzhou General Pharmaceutical Research Institute Co.，Ltd.，Guangzhou 510240，China
4. Xinhua College of Sun Yat-sen University，Guangzhou 510520，China
- Publication Type:Journal Article
- Keywords:
Imperatorin;
Ultradeformable liposomes;
Gel;
Formulation optimization;
Preparation;
Quality evaluation
- From:
China Pharmacy
2020;31(9):1074-1079
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To prepare Imperatorin ultradeformable liposomes gel （IMP-UDLs-Gel），and to evaluate its quality. METHODS：Based on single factor test ，using 12 h accumulative penetration amount （Q12h）as evaluation index ，the proportion of carbomer 940，glycerol and propyl glycol in formulation of IMP-UDLs-Gel were investigated by orthogonal test. The optimal formulation was screened. The quality of IMP-UDLs-Gel prepared with the optimal formulation was evaluated. RESULTS ：The optimal formulation of IMP-UDLs-Gel included carbomer 940 proportion of 1％，glycerol proportion of 15％ and propyl glycol proportion of 10％. Q12 h of IMP-UDLs-Gel was （11.543±0.241）μg/cm2；the appearance was milky white and translucent ；the particle size was （93.13±1.68）nm，PDI was 0.268±0.012，Zeta potential was （－24.96±1.99）mV；pH was 7.32±0.03； viscosity was （45.37±1.27）g·s；steady flow was （0.727±0.002）μg·h/cm2，lag time was （4.358±0.175）h，apparent permeability coefficient was 1.392×10－3 cm/h，and it has good physical and optical stability. CONCLUSIONS ：The preparation method is stable and feasible ，and the prepared IMP-UDLs-Gel has good adhesion ，stability and transdermal property.
