Nasal eosinophilic angiocentric fibrosis with IgG4-positive plasma cell infiltration
- Author:
Saenz-Ibarra B.
1
Author Information
1. Anatomical Pathology and Cytopathology Department, University Hospital Dr. Jose Eleuterio Gonzalez UANL, Francisco I. Madero y Gonzalitos S/N, 64460 Monterrey, Nuevo Leon, Mexico
- Collective Name:Ceceñas-Falcon L.A.; Cardenas-De la Garza, J.A.; Garza-Elizondo, M.A; De Hoyos, R.; Dieste, M.; Barboza-Quintana, O.
- Publication Type:Case Reports
- Keywords:
eosinophilic angiocentric fibrosis;
IgG4-related disease;
IgG4 immunoglobulin;
nasal mass;
rheumatic disease
- From:The Malaysian Journal of Pathology
2020;42(1):137-141
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Eosinophilic angiocentric fibrosis (EAF) is a rare lesion that predominantly affects the upper respiratory tract. Its etiology is unknown and it has been recently associated with the IgG4related disease (IgG4-RD) spectrum. To the author’s knowledge, this is the sixth case report of the relationship between EAF and IgG4-RD. Case Report: We report the case of a 37-year-old woman with nasal deformity and facial pain. The lesion was surgically excised. Histological examination revealed features of EAF with an IgG4/IgG plasma cell ratio >73% and 31 IgG4 stained cells per high power field. No clinical or radiological recurrence was detected during follow-up. Serum IgG4 quantification one year after surgery was within normal limits. Discussion: The relationship between both entities may have therapeutic impact because IgG4-RD of the head and neck has a high remission rate with corticosteroids and immunosuppressive therapy. Additional reports of this infrequent disease are necessary to elucidate appropriate treatment and prognosis.
- Full text:5.2020my01055.pdf
