Cytohistology of morule in cribriform-morular variant of papillary thyroid carcinoma
- Author:
Kouhei Sakurai
- Collective Name:Takanori Onouchi; Seiji Yamada; Youichirou Baba; Tetsuya Murata; Tetsuya Tsukamoto; Makoto Kuroda’ Makoto Urano
- Publication Type:Case Reports
- Keywords:
Papillary thyroid carcinoma;
cribriform-morular variant;
morule
- From:The Malaysian Journal of Pathology
2019;41(3):339-343
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Cribriform-morular variant (CMV) is a rare variant of papillary thyroid carcinoma. It frequently occurs in association with familial adenomatous polyposis (FAP), although some cases are sporadic. Herein, we report a case of CMV and analyse morule cytohistology. Case Report: The patient was a 47-year-old woman with no familial history of FAP. A 3.0-cm unifocal mass was identified in the left thyroidal lobe. Fine-needle aspiration cytology revealed papillary clusters of atypical cells with nuclear grooves, which was suspected to be conventional papillary thyroid carcinoma. Histologically, the tumour comprised a papillary and cribriform growth of atypical cells with cytoplasmic accumulation and nuclear translocation of b-catenin. In addition, frequent morule formation was identified. Discussion: In this case, we performed morule analysis through correlative light and electron microscopy (CLEM), and revealed its ultrastructure. Although CMV is a rare form of thyroid carcinoma, it should be considered along with its distinct clinicopathological characteristics.
- Full text:5.2019my01029.pdf
